Randomized, controlled trial of high-dose influenza vaccine among frail residents of long-term care facilities.

ABSTRACT:

Background

Despite vaccination, residents of long-term-care facilities (LTCFs) remain at high risk of influenza-related morbidity and mortality. More-effective vaccine options for this population are needed.

Methods

We conducted a single-blinded, randomized, controlled trial comparing high-dose (HD) to standard-dose (SD) inactivated influenza vaccine (IIV) in 205 frail, elderly residents of LTCFs during the 2011-2012 and 2012-2013 influenza seasons. Hemagglutination inhibition (HI) antibody titers were measured at baseline and 30 and 180 days following vaccination.

Results

A total of 187 subjects (91%) completed the study. The mean age was 86.7 years. Geometric mean titers (GMTs) were significantly higher (P < .05) at day 30 for HD recipients, compared with SD recipie

SUBMITTER: Nace DA 

PROVIDER: S-EPMC4539906 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature