Unknown

Dataset Information

0

MicroRNA-7/NF-κB signaling regulatory feedback circuit regulates gastric carcinogenesis.


ABSTRACT: MicroRNAs play essential roles in gene expression regulation during carcinogenesis. Here, we investigated the role of miR-7 and the mechanism by which it is dysregulated in gastric cancer (GC). We used genome-wide screenings and identified RELA and FOS as novel targets of miR-7. Overexpression of miR-7 repressed RELA and FOS expression and prevented GC cell proliferation and tumorigenesis. These effects were clinically relevant, as low miR-7 expression was correlated with high RELA and FOS expression and poor survival in GC patients. Intriguingly, we found that miR-7 indirectly regulated RELA activation by targeting the IκB kinase IKKε. Furthermore, IKKε and RELA can repress miR-7 transcription, which forms a feedback circuit between miR-7 and nuclear factor κB (NF-κB) signaling. Additionally, we demonstrate that down-regulation of miR-7 may occur as a result of the aberrant activation of NF-κB signaling by Helicobacter pylori infection. These findings suggest that miR-7 may serve as an important regulator in GC development and progression.

SUBMITTER: Zhao XD 

PROVIDER: S-EPMC4539989 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC4731824 | biostudies-literature
2022-06-23 | GSE184512 | GEO
| S-EPMC3916099 | biostudies-literature
| S-EPMC3567829 | biostudies-literature
| S-EPMC7708822 | biostudies-literature
| S-EPMC9265032 | biostudies-literature
| S-EPMC6999715 | biostudies-literature
| S-EPMC6463669 | biostudies-literature
| S-EPMC5381725 | biostudies-literature
| S-EPMC7710319 | biostudies-literature