Acetaminophen Adducts Detected in Serum of Pediatric Patients With Acute Liver Failure.

ABSTRACT:

Objectives

Previous studies in patients with acute liver failure identified acetaminophen (APAP) protein adducts in the serum of 12% and 19% of children and adults, respectively, with acute liver failure of indeterminate etiology. This article details the testing of APAP adducts in a subset (n = 393) of patients with varied diagnoses in the Pediatric Acute Liver Failure Study Group (PALFSG).

Methods

Serum samples were available from 393 participants included in the PALFSG registry. Adduct measurement was performed using validated methods. Participants were grouped by diagnostic category as known APAP overdose, known other diagnosis, and indeterminate etiology. Demographic and clinical characteristics and participant outcomes were compared by adduct status (positive or negati

SUBMITTER: Alonso EM 

PROVIDER: S-EPMC4540211 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature