Dataset Information

Multiple pathologies are common and related to dementia in the oldest-old: The 90+ Study.

ABSTRACT:

Objective

The purpose of this study was to examine the role of multiple pathologies in the expression of dementia in the oldest-old.

Methods

A total of 183 participants of The 90+ Study with longitudinal follow-up and autopsy were included in this clinical-pathologic investigation. Eight pathologic diagnoses (Alzheimer disease [AD], microinfarcts, hippocampal sclerosis, macroinfarcts, Lewy body disease, cerebral amyloid angiopathy, white matter disease, and others) were dichotomized. We estimated the odds of dementia in relation to each individual pathologic diagnosis and to the total number of diagnoses. We also examined dementia severity in relation to number of pathologic diagnoses.