Preclinical approaches to study the biology and treatment of brain metastases.

ABSTRACT: Metastatic spread to the central nervous system (CNS) is a common and devastating manifestation of major cancer types. Its incidence is associated with poor prognosis manifested by neurological deterioration leading to diminished quality of life and an extremely short median survival. CNS metastasis is becoming an increasingly important clinical problem. This is especially the case for certain types of cancers for which effective treatments of visceral disease are available. As a result of the present limitations in treating CNS metastases, this manifestation of tumor progression remains an unmet clinical need. Despite its significance, our general understanding of the mechanisms that regulate the brain-metastatic phenotype is currently meager. Both the analysis of mechanistic aspects of b

SUBMITTER: Cruz-Munoz W 

PROVIDER: S-EPMC4540600 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature