Calpain-2 Inhibitor Therapy Reduces Murine Colitis and Colitis-associated Cancer.

ABSTRACT:

Background

An important role has emerged for calpain enzymes in regulating inflammation with one isoform, calpain-2, particularly important for macrophage activation. The goal of this study was to determine the therapeutic potential of a synthetic calpain-2 inhibitor, zLLY-CH2F, for colitis and inflammation-associated colorectal cancer.

Methods

Mice were then subjected to the azoxymethane/dextran sulfate sodium model of colitis and colitis-associated cancer incorporating intervention with daily injections of 0.75 mg/kg calpain-2 inhibitor beginning after the first signs of colitis.

Results

Calpain-2 inhibitor treatment alleviated weight loss and bloody diarrhea, and reduced inflammatory infiltration into colon tissues and inflammatory cytokine mRNA. Calpain-2 inhibito

SUBMITTER: Rose AH 

PROVIDER: S-EPMC4540674 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature