Inhibition of tumor progression during allergic airway inflammation in a murine model: significant role of TGF-β.

ABSTRACT:

Introduction

TGF-β is an important mediator of pulmonary allergic inflammation, and it has been recently reported to be a potential inhibitor of lung tumor progression. The correlation between cancer and allergic inflammatory diseases remains controversial. Thus, the aim of the present study was to evaluate the effects of pulmonary allergic inflammation and in particular the role of TGF-β on cancer progression.

Methods

Cancer cells were implanted in a BALB/c mice model of allergic airway inflammation, and tumor growth was measured. Apoptosis was evaluated by TUNEL assay, and TGF-β was measured by ELISA. Expression of proliferating cell nuclear antigen, TGF-β, TGF-β receptors I and II, phospho-Smad2 and phospho-Smad4 was evaluated by immunohistochemistry and quantified using

SUBMITTER: Tirado-Rodriguez B 

PROVIDER: S-EPMC4540764 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature