Identification of Allorecognition Loci in Neurospora crassa by Genomics and Evolutionary Approaches.

ABSTRACT: Understanding the genetic and molecular bases of the ability to distinguish self from nonself (allorecognition) and mechanisms underlying evolution of allorecognition systems is an important endeavor for understanding cases where it becomes dysfunctional, such as in autoimmune disorders. In filamentous fungi, allorecognition can result in vegetative or heterokaryon incompatibility, which is a type of programmed cell death that occurs following fusion of genetically different cells. Allorecognition is genetically controlled by het loci, with coexpression of any combination of incompatible alleles triggering vegetative incompatibility. Herein, we identified, characterized, and inferred the evolutionary history of candidate het loci in the filamentous fungus Neurospora crassa. As characterize

SUBMITTER: Zhao J 

PROVIDER: S-EPMC4540973 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature