Comparative effectiveness and tolerance of treatments for Helicobacter pylori: systematic review and network meta-analysis.

ABSTRACT:

Objective

To determine the most efficacious treatment for eradication of Helicobacter pylori with the lowest likelihood of some common adverse events among pre-recommended and newer treatment regimens.

Design

Systematic review and network meta-analysis.

Data sources

Cochrane Library, PubMed, and Embase without language or date restrictions.

Study selection

Full text reports of randomised controlled trials that compared different eradication treatments for H pylori among adults.

Results

Of the 15,565 studies identified, 143 were eligible and included. Data on 14 kinds of treatments were available. Of 91 possible comparisons for the efficacy outcome, 34 were compared directly and the following treatments performed better: seven days of concomitant treatmen

SUBMITTER: Li BZ 

PROVIDER: S-EPMC4541168 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature