Influence of the hTERT rs2736100 polymorphism on telomere length in gastric cancer.

ABSTRACT:

Aim

To investigate the functional consequences of rs2736100 polymorphism in telomere length and examine its link to gastric cancer risk.

Methods

Telomere length and human telomerase reverse transcriptase (hTERT) mRNA expression were measured in 35 gastric cancer tissues and 5 cell lines and correlated to rs2736100 polymorphism. The relationship between rs2736100 polymorphism and the risk of gastric cancer were examined in 243 gastric cancer patients and 246 healthy individuals.

Results

The rs2736100 A allele carrier is closely associated with reduced hTERT mRNA expression and shortened telomere length in gastric cancer tissue and cell lines. When gastric cancers were stratified by histological subtype, telomere length and hTERT mRNA levels were significantly increased

SUBMITTER: Choi BJ 

PROVIDER: S-EPMC4541384 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature