Development of an in vitro model system for studying the interaction of Equus caballus IgE with its high-affinity receptor FcεRI.

ABSTRACT: The interaction of IgE with its high-affinity Fc receptor (FcεRI) followed by an antigenic challenge is the principal pathway in IgE mediated allergic reactions. As a consequence of the high affinity binding between IgE and FcεRI, along with the continuous production of IgE by B cells, allergies usually persist throughout life, with currently no permanent cure available. Horses, especially race horses, which are commonly inbred, are a species of mammals that are very prone to the development of hypersensitivity responses, which can seriously affect their performance. Physiological responses to allergic sensitization in horses mirror that observed in humans and dogs. In this paper we describe the development of an in situ assay system for the quantitative assessment of the release of mediat

SUBMITTER: Sabban S 

PROVIDER: S-EPMC4541457 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature