Steroid sparing effect of omalizumab in seropositive allergic bronchopulmonary aspergillosis.

ABSTRACT:

Background

Allergic bronchopulmonary aspergillosis (ABPA) is a common serious hypersensitivity reaction to airway colonization with Aspergillus in patients with asthma or cystic fibrosis. While steroids are effective in controlling the respiratory symptoms of ABPA, they have many side effects that make them undesirable for long term use. Antifungals have been used to reduce dependency on systemic steroids but long term use can be limited by side effects and there is the possibility of developing resistance to azoles. Some clinicians have successfully used anti-immunoglobulin E (anti-IgE) therapy in various populations, though it is frequently added to antifungals.

Objective

Further describe the utility of anti-IgE therapy for ABPA for patients unable to tolerate antifungals.

SUBMITTER: Beam KT 

PROVIDER: S-EPMC4541638 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature