Evolution of Gastric Cancer Treatment: From the Golden Age of Surgery to an Era of Precision Medicine.

ABSTRACT: Gastric cancer imposes a global health burden. Although multimodal therapies have proven to benefit patients with advanced diseases after curative surgery, the prognosis of most advanced cancer patients still needs to be improved. Surgical extirpation is the mainstay of gastric cancer treatment. Indeed, without curative surgery, variations and combinations of chemotherapy and/or radiation cannot bring clinically meaningful success. Centered around D2 surgery, adjuvant and peri-operative multimodal therapies have improved survival in a certain group of gastric cancer patients. Moving toward a personalized cancer therapy era, molecular targeted strategies have been tested in clinical trials for gastric cancer. With some success and failures, we have learned valuable lessons regarding the bio

SUBMITTER: Choi YY 

PROVIDER: S-EPMC4541645 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature