Population pharmacokinetics of levamisole in children with steroid-sensitive nephrotic syndrome.

ABSTRACT:

Aim

The aim was to investigate the population pharmacokinetics of levamisole in children with steroid-sensitive nephrotic syndrome.

Methods

Non-linear mixed effects modelling was performed on samples collected during a randomized controlled trial. Samples were collected from children who were receiving 2.5 mg kg(-1) levamisole (or placebo) orally once every other day. One hundred and thirty-six plasma samples were collected from 38 children from India and Europe and included in the analysis. A one compartment model described the data well.

Results

The apparent clearance rate (CL/F) and distribution volume (V/F) were 44 l h(-1) 70 kg(-1) and 236 l 70 kg(-1) , respectively; estimated interindividual variability was 32-42%. In addition to allometric scaling of CL/F and V

SUBMITTER: Kreeftmeijer-Vegter AR 

PROVIDER: S-EPMC4541972 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature