Ontology highlight
ABSTRACT: Background
Education has been robustly associated with cognitive reserve and dementia, but not with the rate of cognitive aging, resulting in some confusion about the mechanisms of cognitive aging. This study uses longitudinal data to differentiate between trajectories indicative of healthy versus pathological cognitive aging.Methods
Participants included 9,401 Health and Retirement Study respondents aged 55 and older who completed cognitive testing regularly over 17.3 years until most recently in 2012. Individual-specific random change-point modeling was used to identify age of incident pathological decline; acceleration is interpreted as indicating likely onset of pathological decline when it is significant and negative.Results
These methods detect incident dement
SUBMITTER: Clouston SA
PROVIDER: S-EPMC4542007 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature