Randomized Controlled Trial of Intensive Versus Conservative Glucose Control in Patients Undergoing Coronary Artery Bypass Graft Surgery: GLUCO-CABG Trial.

ABSTRACT:

Objective

The optimal level of glycemic control needed to improve outcomes in cardiac surgery patients remains controversial.

Research design and methods

We randomized patients with diabetes (n = 152) and without diabetes (n = 150) with hyperglycemia to an intensive glucose target of 100-140 mg/dL (n = 151) or to a conservative target of 141-180 mg/dL (n = 151) after coronary artery bypass surgery (CABG) surgery. After the intensive care unit (ICU), patients received a single treatment regimen in the hospital and 90 days postdischarge. Primary outcome was differences in a composite of complications, including mortality, wound infection, pneumonia, bacteremia, respiratory failure, acute kidney injury, and major cardiovascular events.

Results

Mean glucose in the ICU was

SUBMITTER: Umpierrez G 

PROVIDER: S-EPMC4542267 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature