Differential Ability of Primary HIV-1 Nef Isolates To Downregulate HIV-1 Entry Receptors.

ABSTRACT:

Unlabelled

HIV-1 Nef downregulates the viral entry receptor CD4 as well as the coreceptors CCR5 and CXCR4 from the surface of HIV-infected cells, and this leads to promotion of viral replication through superinfection resistance and other mechanisms. Nef sequence motifs that modulate these functions have been identified via in vitro mutagenesis with laboratory HIV-1 strains. However, it remains unclear whether the same motifs contribute to Nef activity in patient-derived sequences and whether these motifs may differ in Nef sequences isolated at different infection stages and/or from patients with different disease phenotypes. Here, nef clones from 45 elite controllers (EC), 46 chronic progressors (CP), and 43 acute progressors (AP) were examined for their CD4, CCR5, and CXCR4 downr

SUBMITTER: Toyoda M 

PROVIDER: S-EPMC4542390 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature