Ontology highlight
ABSTRACT:
SUBMITTER: Sannino S
PROVIDER: S-EPMC4542698 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Cerebral cortex (New York, N.Y. : 1991) 20140321 9
Genetic variations in catechol-O-methyltransferase (COMT) that modulate cortical dopamine have been associated with pleiotropic behavioral effects in humans and mice. Recent data suggest that some of these effects may vary among sexes. However, the specific brain substrates underlying COMT sexual dimorphisms remain unknown. Here, we report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC) and postero-parieto-temporal cortex of m ...[more]