Nicotine Dependence, Nicotine Metabolism, and the Extent of Compensation in Response to Reduced Nicotine Content Cigarettes.

ABSTRACT:

Introduction

The Food and Drug Administration has the authority to regulate tobacco product constituents, including nicotine, to promote public health. Reducing the nicotine content in cigarettes may lead to lower levels of addiction. Smokers however may compensate by smoking more cigarettes and/or smoking more intensely. The objective of this study was to test whether individual differences in the level of nicotine dependence (as measured by the Fagerstrom Test of Cigarette Dependence [FTCD]) and/or the rate of nicotine metabolism influence smoking behavior and exposure to tobacco toxicants when smokers are switched to reduced nicotine content cigarettes (RNC).

Methods

Data from 51 participants from a previously published clinical trial of RNC were analyzed. Nicotine conten

SUBMITTER: Bandiera FC 

PROVIDER: S-EPMC4542742 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature