Gene Expression Characterization of HPV Positive Head and Neck Cancer to Predict Response to Chemoradiation.

ABSTRACT: Human papillomavirus (HPV) has been shown to have a causal role in the development of head and neck squamous cell carcinoma. While HPV-positive head and neck cancer is associated with a better response to treatment in the majority of patients, there is a subset who does not respond favorably to current therapy. Identification of these patients could prevent unnecessary morbidity and indicate the need for alternative therapeutic options. Tissue samples were obtained from 19 patients with HPV-positive head and neck squamous carcinoma treated with chemoradiation therapy. HPV status was confirmed by polymerase chain reaction analysis through detection of HPV16 E7 in both DNA and RNA. RNA was isolated from tissue samples and subjected to microarray gene expression analysis. In addition to ident

SUBMITTER: Thibodeau BJ 

PROVIDER: S-EPMC4542789 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature