Alveolar macrophage depletion increases the severity of acute inflammation following nonlethal unilateral lung contusion in mice.

ABSTRACT:

Background

Lung contusion (LC) is a common injury resulting from blunt thoracic trauma. LC is an important risk factor for the development acute lung injury, adult respiratory distress syndrome, and ventilator-associated pneumonia, all of which increase mortality from trauma. LC produces a nonspecific immune cellular response. Neutrophil recruitment is known to increase the severity of inflammation during LC. However, the exact role of macrophages in modulating the response to LC has not been well described.

Methods

We used a cortical contusion impactor to induce unilateral LC in mice. Thoracic micro computed tomographic scans of these animals were obtained to document radiologic changes over time following LC. To understand the role of macrophages during LC, liposomal clodr

SUBMITTER: Machado-Aranda D 

PROVIDER: S-EPMC4543300 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature