Small lipidated anti-obesity compounds derived from neuromedin U.

ABSTRACT: A small library of truncated/lipid-conjugated neuromedin U (NmU) analogs was synthesized and tested in vitro using an intracellular calcium signaling assay. The selected, most active analogs were then tested in vivo, and showed potent anorexigenic effects in a diet-induced obese (DIO) mouse model. The most promising compound, NM4-C16 was effective in a once-weekly-dose regimen. Collectively, our findings suggest that short, lipidated analogs of NmU are suitable leads for the development of novel anti-obesity therapeutics.

SUBMITTER: Micewicz ED 

PROVIDER: S-EPMC4543588 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature