Pharmacological actions of nobiletin in the modulation of platelet function.

ABSTRACT:

Background and purpose

The discovery that flavonoids are capable of inhibiting platelet function has led to their investigation as potential antithrombotic agents. However, despite the range of studies on the antiplatelet properties of flavonoids, little is known about the mechanisms by which flavonoids inhibit platelet function. In this study, we aimed to explore the pharmacological effects of a polymethoxy flavonoid, nobiletin, in the modulation of platelet function.

Experimental approach

The ability of nobiletin to modulate platelet function was explored by using a range of in vitro and in vivo experimental approaches. Aggregation, dense granule secretion and spreading assays were performed using washed platelets. Fibrinogen binding, α-granule secretion and calcium mobili

SUBMITTER: Vaiyapuri S 

PROVIDER: S-EPMC4543618 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature