Naloxegol: First oral peripherally acting mu opioid receptor antagonists for opioid-induced constipation.

ABSTRACT: Opioid-induced constipation (OIC) is one of the most troublesome and the most common effects of opioid use leading to deterioration in quality of life of the patients and also has potentially deleterious repercussions on adherence and compliance to opioid therapy. With the current guidelines advocating liberal use of opioids by physicians even for non-cancer chronic pain, the situation is further complicated as these individuals are not undergoing palliative care and hence there cannot be any justification to subject these patients to the severe constipation brought on by opioid therapy which is no less debilitating than the chronic pain. The aim in these patients is to prevent the opioid-induced constipation but at the same time allow the analgesic activity of opioids. Many drugs have bee

SUBMITTER: Anantharamu T 

PROVIDER: S-EPMC4544149 | biostudies-literature | 2015 Jul-Sep

REPOSITORIES: biostudies-literature