Visual Cone Arrestin 4 Contributes to Visual Function and Cone Health.

ABSTRACT:

Purpose

Visual arrestins (ARR) play a critical role in shutoff of rod and cone phototransduction. When electrophysiological responses are measured for a single mouse cone photoreceptor, ARR1 expression can substitute for ARR4 in cone pigment desensitization; however, each arrestin may also contribute its own, unique role to modulate other cellular functions.

Methods

A combination of ERG, optokinetic tracking, immunohistochemistry, and immunoblot analysis was used to investigate the retinal phenotypes of Arr4 null mice (Arr4-/-) compared with age-matched control, wild-type mice.

Results

When 2-month-old Arr4-/- mice were compared with wild-type mice, they had diminished visual acuity and contrast sensitivity, yet enhanced ERG flicker response and higher photopic ERG b-

SUBMITTER: Deming JD 

PROVIDER: S-EPMC4544185 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature