AT1R A1166C variants in patients with type 2 diabetes mellitus and diabetic nephropathy.

ABSTRACT:

Background

There are inconsistent reports related to the role of angiotensin II type 1 receptor (AT1R) on the risk of type 2 diabetes mellitus (T2DM) and its renal complications.

Objectives

To identify the association between AT1R A1166C variants with the risk of T2DM and also with diabetic nephropathy (DN).

Patients and methods

In a case-control study, the AT1R A1166C polymorphism was detected in 135 T2DM patients with and without DN and in 98 healthy subjects from Western Iran. The genotypes of AT1R A1166C polymorphism were detected using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.

Results

The frequencies of AT1R A1166C genotypes and alleles were not significantly difference between patients with and without DN and co

SUBMITTER: Moradi M 

PROVIDER: S-EPMC4544557 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature