Association of common SIX6 polymorphisms with peripapillary retinal nerve fiber layer thickness: the Singapore Chinese Eye Study.

ABSTRACT:

Purpose

Recently the common SIX6 missense variant rs33912345 was found to be highly associated with glaucoma. The aim of this study was to investigate the association between this SIX6 variant and peripapillary retinal nerve fiber layer (RNFL) thickness measured by spectral-domain optical coherence tomography (SD-OCT) in a population setting.

Methods

Study subjects were enrolled from the Singapore Chinese Eye Study (SCES), a population-based survey of Singaporean Chinese aged 40 years or older. Subjects underwent a comprehensive ocular examination. Spectral-domain OCT was used to measure RNFL thicknesses. Genotyping of SIX6 rs33912345 (Asn141His) was performed using HumanExome BeadChip.

Results

A total of 2129 eyes from 1243 SCES subjects (mean age: 55.0 ± 7.4 years)

SUBMITTER: Cheng CY 

PROVIDER: S-EPMC4544593 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature