Effects of ferumoxytol on quantitative PET measurements in simultaneous PET/MR whole-body imaging: a pilot study in a baboon model.

ABSTRACT:

Background

Simultaneous PET/MR imaging depends on MR-derived attenuation maps (mu-maps) for accurate attenuation correction of PET data. Currently, these maps are derived from gradient-echo-based MR sequences, which are sensitive to susceptibility changes. Iron oxide magnetic nanoparticles have been used in the measurement of blood volume, tumor microvasculature, tumor-associated macrophages, and characterizing lymph nodes. Our aim in this study was to assess whether the susceptibility effects associated with iron oxide nanoparticles can potentially affect measured (18)F-FDG PET standardized uptake values (SUV) through effects on MR-derived attenuation maps.

Methods

The study protocol was approved by the Institutional Animal Care and Use Committee. Using a Siemens Biograph m

SUBMITTER: Borra RJ 

PROVIDER: S-EPMC4544618 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature