Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection.

ABSTRACT: Mucosal damage to the gastrointestinal (GI) tract with resulting microbial translocation is hypothesized to significantly contribute to the heightened and persistent chronic inflammation and immune activation characteristic to HIV infection. Here we employ a non-human primate model of chemically induced colitis in SIV-uninfected rhesus macaques that we developed using dextran sulfate sodium (DSS), to directly test this hypothesis. DSS treatment results in GI barrier damage with associated microbial translocation, inflammation and immune activation. The progression and severity of colitis are longitudinally monitored by a magnetic resonance imaging approach. DSS treatment of SIV-infected African green monkeys, a natural host species for SIV that does not manifest GI tract damage or chronic

SUBMITTER: Hao XP 

PROVIDER: S-EPMC4544774 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature