Association between the MUC5B promoter polymorphism and survival in patients with idiopathic pulmonary fibrosis.

ABSTRACT:

Importance

Current prediction models of mortality in idiopathic pulmonary fibrosis (IPF), which are based on clinical and physiological parameters, have modest value in predicting which patients will progress. In addition to the potential for improving prognostic models, identifying genetic and molecular features that are associated with IPF mortality may provide insight into the underlying mechanisms of disease and inform clinical trials.

Objective

To determine whether the MUC5B promoter polymorphism (rs35705950), previously reported to be associated with the development of pulmonary fibrosis, is associated with survival in IPF.

Design, setting, and participants

Retrospective study of survival in 2 independent cohorts of patients with IPF: the INSPIRE cohort, consist

SUBMITTER: Peljto AL 

PROVIDER: S-EPMC4545271 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature