Feedback mechanisms for cardiac-specific microRNAs and cAMP signaling in electrical remodeling.

ABSTRACT:

Background

Loss of transient outward K(+) current (Ito) is well documented in cardiac hypertrophy and failure both in animal models and in humans. Electrical remodeling contributes to prolonged action potential duration and increased incidence of arrhythmias. Furthermore, there is a growing body of evidence linking microRNA (miR) dysregulation to the progression of both conditions. In this study, we examined the mechanistic basis underlying miR dysregulation in electrical remodeling and revealed a novel interaction with the adrenergic signaling pathway.

Methods and results

We first used a tissue-specific knockout model of Dicer1 in cardiomyocytes to reveal the overall regulatory effect of miRs on the ionic currents and action potentials. We then validated the inducible cAMP

SUBMITTER: Myers R 

PROVIDER: S-EPMC4545299 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature