Pharmacokinetics of bisphenol A in humans following a single oral administration.

ABSTRACT:

Background

Human exposures to bisphenol A (BPA) are widespread. The current study addresses uncertainties regarding human pharmacokinetics of BPA.

Objective

To reduce uncertainties about the metabolism and excretion of BPA in humans following oral administration.

Methods

We exposed six men and eight women to 100 μg/kg bw of deuterated BPA (d6-BPA) by oral administration and conducted blood and urine analysis over a three day period. The use of d6-BPA allowed administered d6-BPA to be distinguished from background native (unlabeled) BPA. We calculated the rate of oral absorption, serum elimination, half-life, area under the curve (AUC), urinary excretion, and metabolism to glucuronide and sulfate conjugates.

Results

Mean serum total (unconjugated and conjugated)

SUBMITTER: Thayer KA 

PROVIDER: S-EPMC4545316 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature