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Large C9orf72 repeat expansions are not a common cause of Parkinson's disease.

ABSTRACT: The concept of a pathological overlap between neurodegenerative disorders is gaining momentum. We sought to determine the contribution of C9orf72 repeat expansions, recently discovered as a cause of frontotemporal dementia and amyotrophic lateral sclerosis, in a large number of Parkinson's disease patients. No large expansions were identified in our cohort.

SUBMITTER: Majounie E 

PROVIDER: S-EPMC4545506 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature

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Large C9orf72 repeat expansions are not a common cause of Parkinson's disease.

Majounie Elisa E   Abramzon Yevgeniya Y   Renton Alan E AE   Keller Margaux F MF   Traynor Bryan J BJ   Singleton Andrew B AB  

Neurobiology of aging 20120620 10

The concept of a pathological overlap between neurodegenerative disorders is gaining momentum. We sought to determine the contribution of C9orf72 repeat expansions, recently discovered as a cause of frontotemporal dementia and amyotrophic lateral sclerosis, in a large number of Parkinson's disease patients. No large expansions were identified in our cohort. ...[more]

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