Gender disparities in the tumor genetics and clinical outcome of multiple myeloma.

ABSTRACT:

Background

Several cancer types have differences in incidence and clinical outcome dependent on gender, but these are not well described in myeloma. The aim of this study was to characterize gender disparities in myeloma.

Methods

We investigated the association of gender with the prevalence of tumor genetic lesions and the clinical outcome of 1,960 patients enrolled in the phase III clinical trial MRC Myeloma IX. Genetic lesions were characterized by FISH.

Results

Disparities were found in the prevalence of primary genetic lesions with immunoglobulin heavy chain gene (IGH) translocations being more common in women (50% of female patients vs. 38% of male patients, P < 0.001) and hyperdiploidy being more common in men (50% female vs. 62% male, P < 0.001). There were als

SUBMITTER: Boyd KD 

PROVIDER: S-EPMC4545514 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature