Developmental meta-analyses of the functional neural correlates of bipolar disorder.

ABSTRACT:

Importance

Bipolar disorder (BD) is a debilitating mental illness associated with high costs to diagnosed individuals and society. Within the past 2 decades, increasing numbers of children and adolescents have been diagnosed as having BD. While functional magnetic resonance imaging (fMRI) studies have begun to investigate the neural mechanisms underlying BD, few have directly compared differences in youths with BD and adults with BD (hereafter BD-youths and BD-adults, respectively).

Objective

To test the hypothesis that BD-youths (<18 years old) would show greater convergence of amygdala hyperactivation and prefrontal cortical hypoactivation vs BD-adults.

Data sources

PubMed and PsycINFO databases were searched on July 17, 2013, for original, task-related coordinate-b

SUBMITTER: Wegbreit E 

PROVIDER: S-EPMC4545589 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature