Joint prognostic effect of obesity and chronic systemic inflammation in patients with metastatic colorectal cancer.

ABSTRACT:

Background

Obesity is strongly linked with chronic systemic inflammation, and each has been linked with disease progression and survival in patients with colorectal cancer (CRC). The authors investigated the joint prognostic effects of obesity and circulating cytokines in patients with metastatic CRC (mCRC), an understudied patient group.

Methods

In 242 chemotherapy-naive patients with mCRC, the authors measured a multiplex cytokine panel and abstracted clinicopathological features, height, and weight from medical records. Overall survival (OS) was calculated from the date of mCRC diagnosis until the date of death from any cause and evaluated by Kaplan-Meier analysis and multivariable Cox proportional hazards regression models. Cut points for cytokines were determined by res

SUBMITTER: Shah MS 

PROVIDER: S-EPMC4545691 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature