Assessing breast cancer cell lines as tumour models by comparison of mRNA expression profiles.

ABSTRACT:

Introduction

Breast cancer researchers use cell lines to model myriad phenomena ranging from DNA repair to cancer stem cell phenotypes. Though appropriate, and even requisite, for many studies, the suitability of cell lines as tumour models has come into question owing to possibilities of tissue culture artefacts and clonal selection. These issues are compounded by the inability of cancer cells grown in isolation to fully model the in situ tumour environment, which also contains a plethora of non-tumour cell types. It is thus important to understand similarities and differences between cancer cell lines and the tumours that they represent so that the optimal tumour models can be chosen to answer specific research questions.

Methods

In the present study, we compared the RNA-s

SUBMITTER: Vincent KM 

PROVIDER: S-EPMC4545915 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature