Inhibition by stabilization: targeting the Plasmodium falciparum aldolase-TRAP complex.

ABSTRACT:

Background

Emerging resistance of the malaria parasite Plasmodium to current therapies underscores the critical importance of exploring novel strategies for disease eradication. Plasmodium species are obligate intracellular protozoan parasites. They rely on an unusual form of substrate-dependent motility for their migration on and across host-cell membranes and for host cell invasion. This peculiar motility mechanism is driven by the 'glideosome', an actin-myosin associated, macromolecular complex anchored to the inner membrane complex of the parasite. Myosin A, actin, aldolase, and thrombospondin-related anonymous protein (TRAP) constitute the molecular core of the glideosome in the sporozoite, the mosquito stage that brings the infection into mammals.

Methods

Virtual libra

SUBMITTER: Nemetski SM 

PROVIDER: S-EPMC4545932 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature