DNA methylation and gene expression dynamics during spermatogonial stem cell differentiation in the early postnatal mouse testis.

ABSTRACT:

Background

In the male germline, neonatal prospermatogonia give rise to spermatogonia, which include stem cell population (undifferentiated spermatogonia) that supports continuous spermatogenesis in adults. Although the levels of DNA methyltransferases change dynamically in the neonatal and early postnatal male germ cells, detailed genome-wide DNA methylation profiles of these cells during the stem cell formation and differentiation have not been reported.

Results

To understand the regulation of spermatogonial stem cell formation and differentiation, we examined the DNA methylation and gene expression dynamics of male mouse germ cells at the critical stages: neonatal prospermatogonia, and early postntal (day 7) undifferentiated and differentiating spermatogonia. We found lar

SUBMITTER: Kubo N 

PROVIDER: S-EPMC4546090 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature