Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.

ABSTRACT: An analysis of gene expression variability can provide an insightful window into how regulatory control is distributed across the transcriptome. In a single cell analysis, the inter-cellular variability of gene expression measures the consistency of transcript copy numbers observed between cells in the same population. Application of these ideas to the study of early human embryonic development may reveal important insights into the transcriptional programs controlling this process, based on which components are most tightly regulated. Using a published single cell RNA-seq data set of human embryos collected at four-cell, eight-cell, morula and blastocyst stages, we identified genes with the most stable, invariant expression across all four developmental stages. Stably-expressed genes were

SUBMITTER: Hasegawa Y 

PROVIDER: S-EPMC4546122 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature