Reliever salbutamol use as a measure of exacerbation risk in chronic obstructive pulmonary disease.

ABSTRACT:

Background

Debate exists regarding which endpoints most sensitively reflect day-to-day variation in chronic obstructive pulmonary disease (COPD) symptoms and are most useful in clinical practice to predict COPD exacerbations. We hypothesized that short-acting β2-agonist (SABA) reliever use would predict short- and long-term exacerbation risk in COPD patients.

Methods

We performed a retrospective analysis of data from a study (ClinicalTrials.gov registration: NCT00419744) comparing budesonide/formoterol 320/9 μg with formoterol 9 μg (both twice daily) in patients with moderate-to-very-severe COPD; reliever salbutamol 90 μg was provided. First occurrence of reliever use >4 (low), >10 (medium), and >20 (high) inhalations/day was assessed as a predictor of short-term (3-week) ex

SUBMITTER: Jenkins CR 

PROVIDER: S-EPMC4546184 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature