Evolutionary Consequence of a Trade-Off between Growth and Maintenance along with Ribosomal Damages.

ABSTRACT: Microorganisms in nature are constantly subjected to a limited availability of resources and experience repeated starvation and nutrition. Therefore, microbial life may evolve for both growth fitness and sustainability. By contrast, experimental evolution, as a powerful approach to investigate microbial evolutionary strategies, often targets the increased growth fitness in controlled, steady-state conditions. Here, we address evolutionary changes balanced between growth and maintenance while taking nutritional fluctuations into account. We performed a 290-day-long evolution experiment with a histidine-requiring Escherichia coli strain that encountered repeated histidine-rich and histidine-starved conditions. The cells that experienced seven rounds of starvation and re-feed grew more sustai

SUBMITTER: Ying BW 

PROVIDER: S-EPMC4546238 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature