Gastric bypass surgery has a weight-loss independent effect on post-challenge serum glucose levels.

ABSTRACT:

Background

Gastric bypass surgery seems to have an effect on glucose metabolism beyond what is mediated through weight reduction. The magnitude of this effect on fasting and post-challenge glucose levels remains unknown.

Results

Morbidly obese subjects without known diabetes performed a 75 g oral glucose tolerance test before and after either gastric bypass surgery (n = 64) or an intensive lifestyle intervention programme (n = 55), ClinicalTrials.gov identifier NCT00273104. The age-adjusted effects of the therapeutic procedures and percentage weight change on fasting and 2-h glucose levels at 1 year were explored using multiple linear regression analysis. Mean (SD) serum fasting and 2-h glucose levels at baseline did not differ between the surgery and lifestyle groups. Weigh

SUBMITTER: Hofso D 

PROVIDER: S-EPMC4546335 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature