Cortical contributions to impaired contour integration in schizophrenia.

ABSTRACT:

Objectives

Visual perceptual organization impairments in schizophrenia (SCZ) are well established, but their neurobiological bases are not. The current study used the previously validated Jittered Orientation Visual Integration (JOVI) task, along with fMRI, to examine the neural basis of contour integration (CI), and its impairment in SCZ. CI is an aspect of perceptual organization in which multiple distinct oriented elements are grouped into a single continuous boundary or shape.

Methods

On the JOVI, five levels of orientational jitter were added to non-contiguous closed contour elements embedded in background noise to progressively increase the difficulty in perceiving contour elements as left- or right-pointing ovals. Multi-site fMRI data were analyzed for 56 healthy cont

SUBMITTER: Silverstein SM 

PROVIDER: S-EPMC4546547 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature