Formation and Dynamics of Waves in a Cortical Model of Cholinergic Modulation.

ABSTRACT: Acetylcholine (ACh) is a regulator of neural excitability and one of the neurochemical substrates of sleep. Amongst the cellular effects induced by cholinergic modulation are a reduction in spike-frequency adaptation (SFA) and a shift in the phase response curve (PRC). We demonstrate in a biophysical model how changes in neural excitability and network structure interact to create three distinct functional regimes: localized asynchronous, traveling asynchronous, and traveling synchronous. Our results qualitatively match those observed experimentally. Cortical activity during slow wave sleep (SWS) differs from that during REM sleep or waking states. During SWS there are traveling patterns of activity in the cortex; in other states stationary patterns occur. Our model is a network composed o

SUBMITTER: Roach JP 

PROVIDER: S-EPMC4546669 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature