Invasion of ovarian cancer cells is induced byPITX2-mediated activation of TGF-β and Activin-A.

ABSTRACT:

Background

Most ovarian cancers are highly invasive in nature and the high burden of metastatic disease make them a leading cause of mortality among all gynaecological malignancies. The homeodomain transcription factor, PITX2 is associated with cancer in different tissues. Our previous studies demonstrated increased PITX2 expression in human ovarian tumours. Growing evidence linking activation of TGF-β pathway by homeodomain proteins prompted us to look for the possible involvement of this signalling pathway in PITX2-mediated progression of ovarian cancer.

Methods

The status of TGF-β signalling in human ovarian tissues was assessed by immunohistochemistry. The expression level of TGFB/INHBA and other invasion-associated genes was measured by quantitative-PCR (Q-PCR) and West

SUBMITTER: Basu M 

PROVIDER: S-EPMC4546816 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature