Liver fat, statin use, and incident diabetes: The Multi-Ethnic Study of Atherosclerosis.

ABSTRACT:

Background and aims

To balance competing cardiovascular benefits and metabolic risks of statins, markers of type 2 diabetes (T2D) susceptibility are needed. We sought to define a competing risk/benefit of statin therapy on T2D and cardiovascular disease (CVD) events using liver attenuation and coronary artery calcification (CAC).

Methods and results

3153 individuals from the Multi-Ethnic Study of Atherosclerosis (MESA) without CVD, T2D/impaired fasting glucose, or baseline statin therapy had CT imaging for CAC and hepatic attenuation (hepatic steatosis). Cox models and rates of CVD and T2D were calculated to assess the role of liver attenuation in T2D and the relative risks/benefits of statins on CVD and T2D. 216 T2D cases were diagnosed at median 9.1 years follow-up. High l

SUBMITTER: Shah RV 

PROVIDER: S-EPMC4546884 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature