Orientia, rickettsia, and leptospira pathogens as causes of CNS infections in Laos: a prospective study.

ABSTRACT:

Background

Scrub typhus (caused by Orientia tsutsugamushi), murine typhus (caused by Rickettsia typhi), and leptospirosis are common causes of febrile illness in Asia; meningitis and meningoencephalitis are severe complications. However, scarce data exist for the burden of these pathogens in patients with CNS disease in endemic countries. Laos is representative of vast economically poor rural areas in Asia with little medical information to guide public health policy. We assessed whether these pathogens are important causes of CNS infections in Laos.

Methods

Between Jan 10, 2003, and Nov 25, 2011, we enrolled 1112 consecutive patients of all ages admitted with CNS symptoms or signs requiring a lumbar puncture at Mahosot Hospital, Vientiane, Laos. Microbiological examinations

SUBMITTER: Dittrich S 

PROVIDER: S-EPMC4547322 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature