Nitroreductase-triggered activation of a novel caged fluorescent probe obtained from methylene blue.

ABSTRACT: A near-infrared fluorescent probe based on methylene blue (p-NBMB) was developed for the detection of nitroreductase. Conjugating methylene blue with a p-nitrobenzyl moiety enables it to be activated by nitroreductase-catalyzed 1,6-elimination, resulting in the release of an active methylene blue fluorophore.

SUBMITTER: Bae J 

PROVIDER: S-EPMC4547460 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature