Plasmodium falciparum genetic crosses in a humanized mouse model.

ABSTRACT: Genetic crosses of phenotypically distinct strains of the human malaria parasite Plasmodium falciparum are a powerful tool for identifying genes controlling drug resistance and other key phenotypes. Previous studies relied on the isolation of recombinant parasites from splenectomized chimpanzees, a research avenue that is no longer available. Here we demonstrate that human-liver chimeric mice support recovery of recombinant progeny for the identification of genetic determinants of parasite traits and adaptations.

SUBMITTER: Vaughan AM 

PROVIDER: S-EPMC4547688 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature